MOTS-C for Metabolic and Endurance Research 10mg

* This product is strictly for laboratory research use only and must not be used for human consumption, medical treatments, or any other non-research purposes.

What is MOTS-C?

MOTS-C is a mitochondrial-derived peptide consisting of 16 amino acids, uniquely encoded in mitochondrial DNA rather than nuclear DNA. This peptide plays a crucial role in regulating metabolic functions, cellular energy production, and stress responses. Because of its direct impact on mitochondrial function, MOTS-C has garnered attention in research focused on metabolism, aging, obesity, and endurance.

Mechanism of Action

MOTS-C influences cellular energy by directly affecting pathways that regulate glucose metabolism and insulin sensitivity. Specifically, it activates AMPK (adenosine monophosphate-activated protein kinase), a key energy sensor in the body that helps regulate glucose uptake, fatty acid oxidation, and overall energy balance. By activating AMPK, MOTS-C promotes efficient glucose utilization and can help improve metabolic flexibility.

In addition to AMPK activation, MOTS-C has been shown to inhibit the folate cycle temporarily, shifting energy production pathways to favor glucose metabolism, which is particularly helpful in times of metabolic stress.

Potential Benefits of MOTS-C

1. Improved Insulin Sensitivity: MOTS-C enhances the body’s ability to utilize insulin, making it beneficial in research focused on insulin resistance and type 2 diabetes. Improved insulin sensitivity can help regulate blood sugar levels, reduce fat storage, and improve overall metabolic health.

2. Fat Loss and Weight Management: By improving mitochondrial function and glucose metabolism, MOTS-C can support fat burning and weight loss. Studies suggest that MOTS-C may help reduce fat mass, particularly in individuals with metabolic disorders.

3. Increased Endurance and Physical Performance: MOTS-C's effects on mitochondrial function make it valuable for research on endurance and exercise performance. It enhances the efficiency of energy production in muscle cells, helping to delay fatigue and support longer, more intense workouts.

4. Anti-Aging Effects: Given its mitochondrial origin, MOTS-C has shown potential in slowing down aspects of cellular aging. Improved mitochondrial health is associated with reduced oxidative stress and increased cellular resilience, which are key factors in age-related decline.

5. Potential Neuroprotective Effects: Some research suggests that MOTS-C may protect neurons from oxidative stress, contributing to brain health. While studies are still in early stages, MOTS-C’s impact on mitochondrial function is a promising area for neuroprotection and cognitive research.

Current Research Areas

1. Obesity and Weight Loss: MOTS-C is studied for its impact on body composition, especially regarding fat reduction and weight maintenance. Animal studies have shown promising results in reducing body fat percentage, sparking interest in MOTS-C’s potential as an anti-obesity agent.

2. Diabetes and Metabolic Syndrome: MOTS-C’s ability to regulate glucose uptake and insulin sensitivity has made it a target of research for managing type 2 diabetes and metabolic syndrome. Studies are ongoing to determine how it can improve insulin responses and glucose control.

3. Exercise Endurance and Muscle Health: Given its impact on energy production, MOTS-C is being explored as a performance enhancer, particularly for increasing muscle endurance and strength. Its potential to delay fatigue and support muscle recovery is of particular interest in sports science.

4. Longevity and Anti-Aging: Researchers are examining MOTS-C’s role in longevity and anti-aging, primarily through its impact on mitochondrial health and cellular resilience. This research explores how MOTS-C can counteract age-related mitochondrial dysfunction, potentially slowing down biological aging processes.

5. Neuroprotection: Emerging studies are examining MOTS-C’s effects on brain health, particularly in relation to protecting neurons from oxidative stress and supporting cognitive function. These studies are exploring its potential as a neuroprotective agent that could contribute to the prevention of neurodegenerative diseases.

Dosage and Administration

• Common Research Dosage: 10-15 mg administered subcutaneously, 2-3 times per week.

• Timing: MOTS-C is typically administered in the morning or before physical activity, as its effects on mitochondrial function and glucose metabolism may support energy levels and endurance.

Safety and Potential Side Effects

MOTS-C is still primarily a research peptide, so long-term safety profiles are not yet fully established. However, some reported side effects in studies include:

• Mild Fatigue: Some users report mild fatigue following administration, possibly due to its effects on glucose metabolism.

• Injection Site Reactions: Mild redness or swelling at the injection site can occur.

• Temporary Changes in Blood Sugar Levels: Given its role in glucose regulation, monitoring blood sugar is advisable, especially for those with metabolic conditions.

Additional Research References

For those interested in scientific studies and further research on MOTS-C, consider these sources:

• PubMed: Extensive database of scientific studies, including MOTS-C’s effects on metabolism and aging (PubMed).

• ResearchGate: Access to research papers and studies focused on mitochondrial peptides like MOTS-C (ResearchGate).

• ScienceDirect: Contains research articles on MOTS-C’s influence on mitochondrial health and endurance (ScienceDirect).